Tryptamines are compounds that can be formed when your body breaks down tryptophan, a common amino acid. Tryptamine is a neurotransmitter and neuromodulator. Researchers believe that tryptamine mainly acts on serotonin receptors in the brain. Melatonin and serotonin are considered tryptamines.

Certain amphibians, plants, microbes, and fungi also contain tryptamine. In addition, some tryptamines are psychoactive, which means they produce a hallucinogenic experience when ingested. Examples include psilocybin and dimethyltryptamine (DMT).

Tryptamines are also thought to function as vasodilators and vasoconstrictors. Additionally, tryptamines may have antibacterial, antioxidant, and antimicrobial properties.

Chemically, tryptamines are identified by their benzene ring and pyrrole ring, and a 2-carbon side chain.

Tryptamine Psychedelics

Tryptamine psychedelics are compounds found in natural substances that produce a hallucinogenic experience when ingested.

Tryptamine psychedelics include natural hallucinogens like dimethyltryptamine (DMT), which is found in several plants. 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), which is found in the secretions of the Bufo alvarius toad, is also known as a tryptamine psychedelic.

Tryptamines synthesized in a lab are sometimes referred to as tryptamine derivatives. These substances include manufactured tryptamine psychedelics and migraine medications like sumatriptan.

List of Tryptamines

Tryptamines include the following substances:

  • DMT
  • Psilocin
  • Serotonin
  • Melatonin
  • Psilocybin
  • 5-MeO-DMT
  • Mescaline (peyote)
  • Lysergic acid (LSD)
  • Ayahuasca (its active ingredient is DMT)